In 3rd millennium BC Mesopotamia, Akkad and Subartu are locked in a perpetual war, influenced by their respective deities Marduk and Ishtar. Queen Semiramis of Subartu secretly seeks an alliance with King Sargon of Akkad to protect Nineveh from the thunder god Addad's looming attack, but danger strikes first.
Queen Semiramis and King Sargon arrive in Nineveh, a city at peace, but tensions rise as Akkadian generals build a defensive army against the council's wishes. The citizens distrust their queen's alliance with former enemies, while the thunder god Addad manipulates events, leading to conflict and threatening the city's defenses.