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Focusing on the health challenges faced by autistic children, this study investigates the prevalence of gastrointestinal disorders in this population compared to their peers. It highlights a notable correlation between these disorders and dysfunctional serotoninergic neurotransmission, particularly through the expression of 5-HT2A serotonin receptor mRNA. The findings indicate that autistic children experience gastrointestinal issues more frequently, supported by histopathological evidence, suggesting a need for increased gastroenterological awareness in their care.