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Increasingly transforming entire industries, the boundary spanning concept of disruptive innovation requires business models to change. This book adopts insights from the (activity) system theory and takes a design science approach for the development of an appropriate, comprehensive and structured business model artifact. Based on pattern analysis, the main contribution of this thesis is of design nature, transforming justificatory knowledge into a manageable instrument that supports the process of designing novel business models for disruption. Besides that, a theoretical contribution is made by bridging the knowledge gap of the interrelated disruptive innovation and business model concept.