図像学者ラングドンの元に世界最大の科学研究所セルンの所長から紋章についての問い合わせが入る。それは男の全裸死体に押された焼印で、すでに消滅した、ガリレオが創設したという伝説の秘密結社の紋章だった……おりしもヴァチカンは次期教皇選挙の日。ところが有力候補四人が失踪してしまった……次々起こる見立て殺人。ラングドンは知力の限りを尽くして姿亡き敵を追う！とてつもないスケールで描く驚天動地のラスト！
Robert Langdon, Harvard Professor Of Symbology, Receives An Urgent Late-Night Call While In Paris: The Curator Of The Louvre Has Been Murdered. Alongside The Body Is A Series Of Baffling Ciphers. Langdon And A Gifted French Cryptologist, Sophie Neveu, Are Stunned To Find A Trail That Leads To The Works Of Da Vinci And Further. The Curator, Part Of A Secret Society Named The Priory Of Sion, May Have Sacrificed His Life To Keep Secret The Location Of A Vastly Important Religious Relic Hidden For Centuries. It Appears That The Clandestine Vatican-Sanctioned Catholic Sect Opus Dei Has Now Made Its Move. Unless Landon And Neveu Can Decipher The Labyrinthine Code And Quickly Assemble The Pieces Of The Puzzle, The Priory S Secret And A Stunning Historical Truth Will Be Lost Forever.