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11 September 1683, Rome. The citizens of the city wait anxiously for the outcome of the battle of Vienna as Ottoman forces lay siege to the defenders of Catholic Europe. Meanwhile, a suspected outbreak of plague causes a famous tavern to be placed under quarantine. While detained there, French spy Atto Melani discovers a secret network of passages under the city. They lead him into the Roman underworld and the startling discovery of a plot to assassinate the pope and a plan to use the plague as a weapon of mass destruction in the battle between Islam and the West…