Jean-Nicolas` Vauthey Books

It is now widely accepted that multidisciplinary collaboration and multimodality treatment approaches are important in improving the survival of patients with hepatocellular carcinoma. In this comprehensive textbook, internationally renowned experts in the field present and discuss the various strategies employed in the treatment of the disease. Up-to-date information is provided on the indications for and outcome of a range of treatment options, including surgical resection, liver transplantation, radiofrequency ablation, transarterial chemoembolization, yttrium-90 transarterial radioembolization, and systemic therapy. In addition, important background information is included on biology, pathology, staging, and imaging. This book will be particularly helpful to all professionals and trainees worldwide who have an interest in the diagnosis and treatment of hepatocellular carcinoma.

Recent major advances in the field of comparative genomics and cytogenomics of plants, particularly associated with the completion of ambitious genome projects, have uncovered astonishing facets of the architecture and evolutionary history of plant genomes. The aim of this book was to review these recent developments as well as their implications in our understanding of the mechanisms which drive plant diversity. New insights into the evolution of gene functions, gene families and genome size are presented, with particular emphasis on the evolutionary impact of polyploidization and transposable elements. Knowledge on the structure and evolution of plant sex chromosomes, centromeres and microRNAs is reviewed and updated. Taken together, the contributions by internationally recognized experts present a panoramic overview of the structural features and evolutionary dynamics of plant genomes. This volume of Genome Dynamics will provide researchers, teachers and students in the fields of biology and agronomy with a valuable source of current knowledge on plant genomes.

Our way of understanding evolution has changed completely with the era of genomics, particularly since the emergence of comparative genomics, a discipline allowing the analysis of complete genomes and biological processes over vast periods of time. In this volume, internationally recognized experts present and discuss an update of the evolutionary processes at the onset of organismal diversification and complexity, and review the mechanisms leading to the acquisition of new traits and functions. Different levels of evolution are considered, from internal modules in genes and proteins to interactomes and biological networks, with integration of the influence of both the genomic environment and the ecological context. Particular emphasis will be given to the origin of novel genes and gene functions as well as to the evolutionary impact of the duplication of genetic information, with several chapters devoted to transposable elements. Providing an excellent update on gene and protein evolution, this book will be appreciated by researchers in biology and medicine, biology teachers and anyone interested in evolution and genomics.

The publication of the first draft of the human genome five years ago marked the start of a new era of vertebrate comparative genomics. Genome draft sequences for chimpanzee, mouse, rat, dog, chicken as well as for several fish species are now available for the reconstruction of the evolutionary history of vertebrate genomes over the last 450 million years. This volume of Genome Dynamics presents a timely update on the past, present and future of major vertebrate genome projects. In 16 chapters, renowned specialists provide informative reviews on the current status of mammalian, bird, amphibian and fish genomics. In addition, a chapter on urochordate genomes is included. The reader will also find a useful overview of resources available for each genome as well as a description of the medical and economical perspectives opened by the different projects. This book is recommended reading for biologists interested in genetics, genomics, evolution and zoology.

Cancer and other genetic human diseases are caused by a variety of mutations, ranging from subtle sequence changes to larger genomic rearrangements and alterations in chromosome number (aneuploidy). With contributions by reputed experts, this book aims to update the knowledge on the multiple mechanisms of genomic instability leading to human disease. Emphasis is given to the different types of genomic sequences involved in disease-related genomic rearrangements as well as to the various exogenous factors increasing the frequency of mutations. Several chapters are dedicated to the dysfunction of important cellular mechanisms like DNA repair and chromosome segregation, which may cause genomic instability and result in tumorigenesis. Important ‘caretaker’ genes controlling the stability of our genome have been identified through their defect in genomic instability syndromes, which are also extensively reviewed in this volume. This book provides an important update not only for investigators in biology and medicine, but also for physicians and anyone interested in the molecular basis of human disease.

Retrotransposable elements are major constituents of genomes. These mobile DNA sequences can disrupt genes, induce genomic rearrangements, influence gene expression and mobilize various types of non-autonomous sequences. Their genomic status is still controversial and an object of intense debate in the scientific community. On the one hand, retrotransposable elements are frequently considered as genome parasites or as ‘junk DNA’ causing genetic diseases and evolving as retroviruses. On the other hand, mobile DNA and transposition are driving forces of genome evolution. Many regulatory and coding sequences contain parts of transposable elements that are required for proper expression and function of resident genes and proteins. Some mobile sequences have been domesticated by the host and play important cellular roles. Valuable reading for researchers and teachers involved in genetics, genome structure and evolution, this publication updates the current knowledge on retrotransposition and retrotransposable elements and their impact on gene function and genome evolution.

Der Band beschäftigt sich mit der Rolle des islamisch-sekularen Dialogs im Rahmen des Friedensschlusses nach dem Bürgerkrieg in Tadschikistan

Dans La maison, la ville et les gens Jean-Nicolas Orhon troque sa caméra contre une plume pour nous livrer, sous la forme d’un carnet de voyage et tournage rétrospectif, son expérience et ses réflexions de documentariste, de citoyen, d’homme. En parallèle, le chercheur Nicolas Reeves, qui a accompagné Jean-Nicolas Orhon dans plusieurs de ses voyages, nous livre une réflexion marquante et parsemée d’anecdotes, sur les solutions trouvées par les habitants pour réussir à vivre ensemble dans un espace restreint aux ressources limitées.Au fil de plus de 150 photographies couleur prises au fil des voyages, le lecteur entre dans le quotidien des habitants de onze bidonvilles à travers le monde.

Eine Freundschaft der besonderen Art … Planet Caldoria im Erdjahr 2215. Die Menschheit ist in Gefahr. Der Supercomputer IAHVE hat die Kontrolle über alle Maschinen übernommen und betrachtet die menschliche Art als eine Bedrohung. Stan lebt allein in der Wüste, als er auf einen freundlich gesinnten Roboter trifft, den er auf den Namen Rocky tauft. Es entsteht eine außergewöhnliche Beziehung zwischen diesen beiden Wesen, die das Leben des Jungen vollkommen verändern wird.