Joachim Frank Book order

Focusing on the development of single-particle cryo-electron microscopy (cryo-EM), the book showcases 55 pivotal articles detailing advancements in methods and significant findings related to biological macromolecules. It emphasizes the technique's versatility, requiring no specific symmetries or arrangements, and highlights applications primarily in ribosome structure, membrane channels, and their mechanisms. A commentary sets the stage by discussing conceptual evolution and collaborative contributions, while the latter sections introduce near-atomic resolution structures and innovative computational analysis techniques.

Approaches to the recovery of three-dimensional information on a biological object, which are often formulated or implemented initially in an intuitive way, are concisely described here based on physical models of the object and the image-formation process. Both three-dimensional electron microscopy and X-ray tomography can be captured in the same mathematical framework, leading to closely-related computational approaches, but the methodologies differ in detail and hence pose different challenges. The editors of this volume, Gabor T. Herman and Joachim Frank, are experts in the respective methodologies and present research at the forefront of biological imaging and structural biology. Computational Methods for Three-Dimensional Microscopy Reconstruction will serve as a useful resource for scholars interested in the development of computational methods for structural biology and cell biology, particularly in the area of 3D imaging and modeling.