The book emphasizes the critical role of interdisciplinary collaboration in the fight against cancer, particularly highlighting the integration of mathematics and computer science with biology, immunology, and medicine. It discusses the ongoing efforts to activate and control the immune system in combating neoplastic cells, underscoring the necessity for mathematicians to contribute to research initiatives. While biologists and immunologists lead the charge, the book advocates for the supportive role of mathematics in advancing cancer research and immunological strategies.
Modeling and Applied Mathematics Modeling the behavior of real physical systems by suitable evolution equa tions is a relevant, maybe the fundamental, aspect of the interactions be tween mathematics and applied sciences. Modeling is, however, only the first step toward the mathematical description and simulation of systems belonging to real world. Indeed, once the evolution equation is proposed, one has to deal with mathematical problems and develop suitable simula tions to provide the description of the real system according to the model. Within this framework, one has an evolution equation and the re lated mathematical problems obtained by adding all necessary conditions for their solution. Then, a qualitative analysis should be developed: this means proof of existence of solutions and analysis of their qualitative be havior. Asymptotic analysis may include a detailed description of stability properties. Quantitative analysis, based upon the application ofsuitable methods and algorithms for the solution of problems, ends up with the simulation that is the representation of the dependent variable versus the independent one. The information obtained by the model has to be compared with those deriving from the experimental observation of the real system. This comparison may finally lead to the validation of the model followed by its application and, maybe, further generalization.
This monograph aims to lay the groundwork for the design of a unified mathematical approach to the modeling and analysis of large, complex systems composed of interacting living things. Drawing on twenty years of research in various scientific fields, it explores how mathematical kinetic theory and evolutionary game theory can be used to understand the complex interplay between mathematical sciences and the dynamics of living systems. The authors hope this will contribute to the development of new tools and strategies, if not a new mathematical theory. The first chapter discusses the main features of living systems and outlines a strategy for their modeling. The following chapters then explore some of the methods needed to potentially achieve this in practice. Chapter Two provides a brief introduction to the mathematical kinetic theory of classical particles, with special emphasis on the Boltzmann equation; the Enskog equation, mean field models, and Monte Carlo methods are also briefly covered. Chapter Three uses concepts from evolutionary game theory to derive mathematical structures that are able to capture the complexity features of interactions within living systems. The book then shifts to exploring the relevant applications of these methods that can potentially be used to derive specific, usable models. The modeling of social systems in various contexts is the subject of Chapter Five, and an overview of modeling crowd dynamics is given in Chapter Six, demonstrating how this approach can be used to model the dynamics of multicellular systems. The final chapter considers some additional applications before presenting an overview of open problems. The authors then offer their own speculations on the conceptual paths that may lead to a mathematical theory of living systems hoping to motivate future research activity in the field. A truly unique contribution to the existing literature, A Quest Toward a Mathematical Theory of Living Systems is an important book that will no doubt have a significant influence on the future directions of the field. It will be of interest to mathematical biologists, systems biologists, biophysicists, and other researchers working on understanding the complexities of living systems
This monograph aims to lay the groundwork for the design of a unified mathematical approach to the modeling and analysis of large, complex systems composed of interacting living things. Drawing on twenty years of research in various scientific fields, it explores how mathematical kinetic theory and evolutionary game theory can be used to understand the complex interplay between mathematical sciences and the dynamics of living systems. The authors hope this will contribute to the development of new tools and strategies, if not a new mathematical theory. The first chapter discusses the main features of living systems and outlines a strategy for their modeling. The following chapters then explore some of the methods needed to potentially achieve this in practice. Chapter Two provides a brief introduction to the mathematical kinetic theory of classical particles, with special emphasis on the Boltzmann equation; the Enskog equation, mean field models, and Monte Carlo methods are also briefly covered. Chapter Three uses concepts from evolutionary game theory to derive mathematical structures that are able to capture the complexity features of interactions within living systems. The book then shifts to exploring the relevant applications of these methods that can potentially be used to derive specific, usable models. The modeling of social systems in various contexts is the subject of Chapter Five, and an overview of modeling crowd dynamics is given in Chapter Six, demonstrating how this approach can be used to model the dynamics of multicellular systems. The final chapter considers some additional applications before presenting an overview of open problems. The authors then offer their own speculations on the conceptual paths that may lead to a mathematical theory of living systems hoping to motivate future research activity in the field. A truly unique contribution to the existing literature, A Quest Toward a Mathematical Theory of Living Systems is an important book that will no doubt have a significant influence on the future directions of the field. It will be of interest to mathematical biologists, systems biologists, biophysicists, and other researchers working on understanding the complexities of living systems.
This volume collects ten surveys on the modeling, simulation, and applications of active particles using methods ranging from mathematical kinetic theory to nonequilibrium statistical mechanics. The contributing authors are leading experts working in this challenging field, and each of their chapters provides a review of the most recent results in their areas and looks ahead to future research directions. The approaches to studying active matter are presented here from many different perspectives, such as individual-based models, evolutionary games, Brownian motion, and continuum theories, as well as various combinations of these. Applications covered include biological network formation and network theory; opinion formation and social systems; control theory of sparse systems; theory and applications of mean field games; population learning; dynamics of flocking systems; vehicular traffic flow; andstochastic particles and mean field approximation. Mathematicians and other members of the scientific community interested in active matter and its many applications will find this volume to be a timely, authoritative, and valuable resource.
This collection of selected chapters offers a comprehensive overview of state-of-the-art mathematical methods and tools for modeling and analyzing cancer phenomena. Topics covered include stochastic evolutionary models of cancer initiation and progression, tumor cords and their response to anticancer agents, and immune competition in tumor progression and prevention. The complexity of modeling living matter requires the development of new mathematical methods and ideas. This volume, written by first-rate researchers in the field of mathematical biology, is one of the first steps in that direction.
Analysis of nonlinear models and problems is crucial in the application of mathematics to real-world problems. This book approaches this important topic by focusing on collocation methods for solving nonlinear evolution equations and applying them to a variety of mathematical problems. These include wave motion models, hydrodynamic models of vehicular traffic flow, convection-diffusion models, reaction-diffusion models, and population dynamics models. The book may be used as a textbook for graduate courses on collocation methods, nonlinear modeling, and nonlinear differential equations. Examples and exercises are included in every chapter.
This book develops new mathematical methods and tools to model living systems. The material it presents can be used in such real-world applications as immunology, transportation engineering, and economics. The first part of the book deals with deriving general evolution equations that can be customized to particular systems of interest in the applied sciences. The second part of the book deals with various models and applications. The book will be a valuable resource to all involved in modeling complex social systems and living matter in general.
