Michael R. Pinsky Book order

Te practice of intensive care medicine is at the very forefront of titration of treatment andmonitoringresponse. Te substrateofthiscareisthe criticallyill patientwho, by defnition, is at the limits of his or her physiologic reserve. Such patients need immediate, aggressive but balanced life-altering interventions to minimize the detrimental aspects of acute illness and hasten recovery. Treatmentdecisionsandresponsetotherapyareusually assessed by measures of physiologic function, such as assessed by cardio-respiratory monitoring. However, how one uses such information is ofen unclear and rarely supported by prospective clinical trials. In reality, the bedside clinician is forced to rely primarily on physiologic principles in determining the best treatments and response to therapy. However, the physiologic foundation present in practicing physicians is uneven and occasionally supported more by habit or prior training than science. A series of short papers published in Intensive Care Medicine since 2002 under the heading Physiologic Notes attempts to capture the essence of the physiologic perspectives that underpin both our understanding of disease and response to therapy. Tis present volume combines the complete list of these Physiologic Notes up until July 2006 with the ass o cia t ed r e vie w a r tic les o v er t h e s a m e in t er val t ha t a ls o addr ess e d t hes e cen tral issues.

This is the newest volume in the softcover series "Update in Intensive Care Medicine". It takes a novel, practical approach to analyzing hemodynamic monitoring, focusing on the patient and outcomes based on disease, treatment options and relevance of monitoring to direct patient care. It will rapidly become a classic in the approach to patient monitoring and management during critical illness.

This volume covers the most important aspects of cerebral blood flow (CBF) from bench to bedside. It first defines the basic physiology of CBF, those qualities that make it unique or are shared with other organs and their clinical implications. There follows a section on CBF pathophysiology that explores many of the known and proposed mechanisms of cerebral ischemia in stroke and trauma states. The third section describes the numerous and powerful means available to measure blood flow, tissue function and overall perfusion. These are essential measures if one is to assess the effectiveness of therapies aimed at preventing or reversing cerebral ischemia. The final section describes the interesting and often successful recent clinical trials aimed at preventing or reversing cerebral ischemia. This collection of multicenter trial data and their implications in one volume is unique in this field. This book addresses all the major aspects of CBF from basic issues to clinical practice.

This volume provides the latest insights into the basic science and clinical issues related to coronary circulation and myocardial ischemia, organized into four parts. The first section explores the basic physiology of coronary blood flow and its regulation, particularly in the context of atherosclerotic disease. The second part delves into applied physiological aspects, discussing key concepts like pre-conditioning, inflammation, thrombosis, and fibrinolysis, all linked to ventricular pump function. The third section focuses on advanced functional assessments of coronary circulation, moving beyond traditional methods like coronary angiography and nuclear scanning to include innovative technologies such as echocardiographic analysis of tissue blood flow, PET for myocardial viability, rapid nuclear magnetic imaging, and intracoronary ultrasound. The final part examines various therapies for coronary ischemia, including non-thrombotic, anti-thrombotic, and thrombolytic treatments. Topics covered include local control of coronary blood flow, mechanisms of atherosclerosis, the role of inflammation in acute coronary syndromes, and the functional assessment of coronary physiology. Additionally, it discusses the use of beta-blockers, calcium channel blockers, nitrates, and interventional cardiology in treating coronary disease, emphasizing the enhancement of coronary blood flow for myocardial salvage therapy.

A concise yet complete overview of the treatment of cardiovascular instability in the critically ill patient. The authors consider all aspects, ranging from basic physiology and pathophysiology to diagnostic tools and established and novel forms of therapy. The whole is rounded off with an integration of these principles into a series of clinically relevant scenarios.

This monograph focuses on splanchnic function in health and disease. It represents a distillate of the communication that took place at the First International Symposium of Applied Physiol ogy of the Peripheral Circulation, „Splanchnic Circulation: No Longer a Silent Partner.“ The individual chapters roughly follow the individual presentations and display in durable form the con cepts and importance that this symposium achieved. The concept for this annual symposium was the child of An tonio Artigas, who not only recruited sponsorship but also Jean Francois Dhainaut and me to help with the organization and work. We chose the splanchnic circulation as the peripheral cir culatory system to be presented first for many important reasons. Much new information has become available which demon strates, as the title of the symposium implies, that splanchnic function has major influence on the overall expression of health and disease in humans. All aspects of splanchnic physiology, it seems, have been rediscovered to be dynamic, important, and complex in their interactions within individual tissues and among remote tissues and organs. It is hoped that after having reviewed this monograph the reader will agree that the splanchnic circula tion and its organ systems are emerging as important aspects of critical illness and host-defense homeostasis.