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J. Donald Capra

    Dr. Capra is renowned for his pioneering studies on antibody genes, their mutation in autoimmune disorders, and as an early leader in the field of monoclonal antibodies. His work has significantly advanced our understanding of the association between immunoglobulin hypervariable regions and the antibody combining site. He has also made contributions to understanding human B cell development and the mechanisms of antibody diversity. His research enriches our comprehension of the immune system and its dysfunctions.

    Antibody engineering
    • 1997

      Antibody engineering

      • 212 pages
      • 8 hours of reading

      The last decade has witnessed remarkable developments in antibody research and its therapeutic applications. With the methods of molecular biology it is now possible to manipulate the specificities and activities of antibody molecules to generate an almost limitless array of structures for both basic investigations and the clinical setting. The contributions to this volume cover all three domains of the antibody: the variable regions, the relatively neglected but crucial hinge, and the constant region. These studies provide critical structural and functional information about antibodies, while also pointing the way to the construction of molecules with enhanced or even novel properties. Bringing together major experts on antibody engineering, this book is highly recommended to faculty, postdoctoral fellows and graduate students in molecular biology, microbiology, immunology, cancer research and genetics.

      Antibody engineering