Dienogest

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This comprehensive work explores the pharmacology and clinical applications of Dienogest, a synthetic progestin. It begins with an examination of the endocrinological pharmacology and toxicology of Dienogest, detailing its chemical structure and experimental studies on its hormonal effects in various cellular systems. The pharmacokinetics and biotransformation of Dienogest across different animal species and its interaction with microorganisms are also discussed. The book assesses the pharmacological and toxicological profile, including its effectiveness in specific bioassays and studies conducted on primates. In the clinical section, the pharmacokinetics of Dienogest as a standalone treatment and in combination with Ethinylestradiol are analyzed, alongside its biotransformation in humans. The binding studies to various receptors and serum proteins are presented, as well as the impact of Dienogest on calcium influx in human vascular cell cultures. The influence of Dienogest on ovulation and other endocrinological parameters in young women is examined, along with the effects on the hypothalamic-pituitary axis. Pilot studies investigating the contraceptive safety, cycle stability, and tolerability of Dienogest are reported, along with long-term studies on its effects on women's voice function. The book also discusses the antiandrogenic effects of Dienogest and its role in treating endometriosis, including receptor status and c