Molecular pathology and genetics of alport syndrome

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This publication provides a unique review of the immense progress that has been made in Alport syndrome research during the last few years. Written by scientists at the forefront of recent developments, the chapters outline current understanding of the epidemiology, genetics, pathology and clinical features of Alport syndrome. The book also provides extensive description of the structural properties of the glomerular basement membrane, and type IV collagen and its genes that are mutated in the disease. Thorough coverage is given to the nature of the mutations and the phenotypes they cause as well as to present methods for linkage analysis and DNA diagnosis.'Molecular Pathology and Genetics of Alport Syndrome' is not only an important reference for nephrologists and kidney transplantation surgeons but will also interest specialists in internal medicine, pediatrics, urology and genetics.