Chimeric virus-like particles as vaccines

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In recent years the use of chimeric virus-like particles (VLPs) as vaccines and gene vectors has gained increasing importance in both basic and applied research. In this publication 16 groups present their views and experimental data on the expression, morphogenesis, structure and immunogenicity of VLPs derived from hepatitis B virus core or surface protein, HIV gag protein, papillomaviruses, rhinoviruses, and various plant viruses. Classical expression systems of such particles in animal cell cultures are complemented by expression in yeast and transgenic plants. The advantages offered by certain chimeric particles, such as the induction of a cytolytic T lymphocyte immune response following administration of recombinant HBsAg, make VLPs promising candidates for new vaccines. DNA vaccination, a further novel mode of inducing protection against infectious agents, is also considered. Researchers and teachers in virology, immunology, molecular biology and infectious diseases will greatly appreciate this comprehensive survey of an important field of modern vaccine development.