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The structure and function of membrane proteins, although ignored by structural biologists for a long time, are now in the forefront of current research. The 3D structure of an integral membrane protein is intimately dependent on the way the protein assembles into the membrane; in this respect, the insertion of the nascent chain into the lipid bilayer is analogous to the formation of the compact folding intermediates in globular proteins. Containing chapters on 3D structure and assembly, as well as recent methods for modeling and simulation of membrane protein structures, this book serves as an up-to-date introduction to membrane protein assembly and structure.
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Membrane protein assembly, Gunnar von Heijne
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- 1997
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