Signal transduction in Alzheimer's disease

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The important role of neuronal signaling in the pathogenesis of Alzheimer's Disease Alzheimer's Disease is a multifactorial condition with phenotypic characteristics in all cases, even though they may vary in details. Although it is still intractable to treatment, in the past decade, considerable efforts have contributed to understanding its pathogenesis. The role of neuronal signaling in the pattern of Alzheimer's disease has attracted an intense interest in recent years for signaling molecules and signal transduction pathways are the central mediators that propagate signals from the membrane to the nucleus to coordinate appropriate cellular responses. Consequently, in the field of signaling that allows an exploration of upstream (causative) and downstream (consequential) events, knowledge of disease mechanisms has increased most significantly. A better understanding of downstream events will allow better treatment in the future and a consolidation of the current hypotheses to understand the entire disease process. The present issue, written by innovative experts in the field, features most recent findings from kinases to phosphatase and from neuronal to glial signaling.