Hepatitis prevention and treatment

Chronic viral hepatitis is a leading cause of disease and death globally. The hepatitis B virus (HBV) and hepatitis C virus (HCV) present significant challenges due to their unique replication methods and interaction with the host immune system. While antiviral therapy for chronic HBV exists, the emergence of viral resistance highlights the need for new chemotherapeutic agents. The absence of effective cell culture systems for HCV replication and small-animal models has hindered antiviral development, though promising new agents are now in preclinical and clinical stages. This monograph offers a comprehensive overview of Hepatitis Prevention and Treatment, featuring contributions from leading experts. It addresses the molecular biology, immunology, biochemistry, pharmacology, and clinical aspects of chronic HBV and HCV infections. Key topics include the history and epidemiology of both viruses, insights into viral replication mechanisms, the host immune response, and discussions on the current standard of care and potential vaccine development. Emerging therapies and challenges related to existing antiviral treatments are also covered. The volume provides the latest information for researchers and clinicians while offering foundational knowledge for newcomers to the field.