Medical statistics

This publication provides an overview of current advances in statistical methodology for gene mapping and parameter estimation in complex genetic traits. Presenting selected papers from the conference ‘Current Developments in Statistical Methodology for Genetic Architecture of Complex Diseases’ held in Oberwolfach in February 2003, it discusses topics such as statistical population genetics, novel approaches for positional gene identification, statistical modelling of multiple disease loci, haplotype estimation and haplotype association analysis, novel designs for nuclear family studies, whole genome analysis, and analysis of large pedigrees. A valuable single source of information, this collection of reviews will interest statisticians, geneticists, epidemiologists, physicians studying complex traits, and anyone in the scientific community interested in statistical methodology applied to questions that arise in mapping genes for complex traits