Design, synthesis, and application of modular building blocks for structural investigations of functional peptides
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The present work focuses on five objective targets as listed below: 1. Design of disubstituted [1,2,3]-triazolyl-comprising molecular blocks as peptide backbone mimics with locked amide conformation; 2. Development of a valid synthetic approach towards the mentioned triazolyl surrogates with focus on their application in Fmoc-based SPPS; 3. Study of the structure-activity relationship in peptidic molecules using the developed triazolyl blocks on two model systems: a) the potent protease inhibitor sunflower trypsin inhibitor 1 (SFTI-1[1,14]) and b) a peptide-based enzyme maquette of nickel superoxide dismutase (Ni(m7-NH2)); 4. Study of the structural properties of triazolyl patterns in peptidic molecules using molecular dynamic simulations; 5. Development of a valuable system towards the study of PHIP effects in biomolecules based on model peptides comprising an unsaturated alkyne moiety in their side chains.
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Design, synthesis, and application of modular building blocks for structural investigations of functional peptides, Marco Körner
- Language
- Released
- 2013
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- Title
- Design, synthesis, and application of modular building blocks for structural investigations of functional peptides
- Language
- English
- Authors
- Marco Körner
- Publisher
- mbv
- Released
- 2013
- ISBN10
- 3863874110
- ISBN13
- 9783863874117
- Series
- Chemistry
- Category
- University and college textbooks
- Description
- The present work focuses on five objective targets as listed below: 1. Design of disubstituted [1,2,3]-triazolyl-comprising molecular blocks as peptide backbone mimics with locked amide conformation; 2. Development of a valid synthetic approach towards the mentioned triazolyl surrogates with focus on their application in Fmoc-based SPPS; 3. Study of the structure-activity relationship in peptidic molecules using the developed triazolyl blocks on two model systems: a) the potent protease inhibitor sunflower trypsin inhibitor 1 (SFTI-1[1,14]) and b) a peptide-based enzyme maquette of nickel superoxide dismutase (Ni(m7-NH2)); 4. Study of the structural properties of triazolyl patterns in peptidic molecules using molecular dynamic simulations; 5. Development of a valuable system towards the study of PHIP effects in biomolecules based on model peptides comprising an unsaturated alkyne moiety in their side chains.