Systems biology

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This work offers a comprehensive overview of systems biology, detailing experimental and computational approaches for studying biological systems. Each chapter serves as an introduction to a specific branch of the field, presenting the current state of research and future directions. It explores integrative analysis methods for omics data and techniques for quantifying carbon fluxes in large metabolic networks, utilizing 13C labelled substrates and genome-scale metabolic models, with examples from Escherichia coli and human metabolism. The authors also discuss the application of these techniques to human health and cell factory engineering, emphasizing advancements in genome-scale models and regulatory networks. They underscore the relevance of this information to various biological processes, such as cellular aging, the immune system, and organogenesis. The book concludes with a discussion on recent genome editing advances, enabling precise genetic modifications and dynamic gene expression control. Part of the Advances in Biotechnology series, it encompasses all critical aspects of the field, with each volume crafted by leading experts.