Essential metals in medicine

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Volume 19 of the Metal Ions in Life Sciences series focuses on the critical role of metal ions in clinical medicine. While essential for life, metal ions can also be toxic, necessitating careful regulation in human health. The book begins with an overview of significant metal-related drugs and diseases, followed by a discussion on drug development. It emphasizes iron's dual role as vital for both humans and pathogens, alongside its potential toxicity. Chelation therapy is explored in relation to thalassemia and neurodegenerative diseases, highlighting the risks associated with iron administration. The essentiality of chromium and vanadium is debated, noting that while chromium(III) is often used as a supplement by athletes, chromate (Cr(VI)) is a known carcinogen. The effects of manganese, cobalt, and copper are also examined. The need for antiparasitic agents and the clinical use of metal-containing antidotes for cyanide poisoning are underscored. The book discusses various metal ions, including harmful ones like arsenic, lead, and cadmium, as well as those used in diagnosis or treatment, such as gadolinium, gallium, lithium, gold, silver, and platinum. With contributions from experts worldwide, the volume includes approximately 2000 references and about 90 illustrations and tables, making it a valuable resource for scientists across multiple disciplines, including pharmacology and biochemistry, as well as for educational pur