pH of the Skin: issues and challenges

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The concept of pH, defined as the negative logarithm of hydrogen ion concentration, emerged in the early 20th century and became essential in life sciences and analytical research. pH measurements from living skin led to the identification of the acid mantle, the skin's natural protective barrier that maintains an acidic pH, vital for skin health. Disruption of this acid mantle through chronic alkalization can result in inflammation, dermatitis, and various skin diseases. Consequently, shifts in skin pH are noted in many skin conditions. The pH of topical preparations is also significant, as optimal pH and buffer capacity enhance the stability of active ingredients and improve the absorption of non-ionized forms of both acidic and basic compounds. Furthermore, these preparations can help modify and restore skin pH, promoting barrier recovery and integrity. There is a pressing need to standardize pH measurements in biological and cosmetic contexts to ensure the quality and relevance of research findings. This volume presents a collection of papers that explore the historical, current, and future implications of skin pH in both healthy and diseased states, aiming to inspire further clinical and experimental research in dermatology.