Enzymatic and chemical synthesis of nucleic acid derivatives

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This practical reference explores innovative tools for creative nucleic acid chemists, emphasizing the growing significance of nucleic acids as diagnostic and therapeutic agents. With contributions from esteemed scientists, it presents a variety of approaches for synthesizing designer nucleic acids and their derivatives. The book details enzymatic methods, including chemo-enzymatic techniques, focusing on the synthesis and incorporation of modified nucleosides. It also reviews non-enzymatic chemical synthesis methods for nucleic acids and their challenging analogs and derivatives. A concise overview of techniques for producing novel, heavily modified polynucleotides in adequate amounts and purity for clinical and research use is provided. This timely guide addresses the expanding market for nucleotide-derived pharmaceuticals, including anti-infectives, chemotherapeutic agents, and agrochemicals. It highlights novel methods and recent trends in the field, featuring insights from an international panel of experts. Aimed at biochemists, medicinal chemists, natural products chemists, organic chemists, and biotechnologists, this resource serves as a practice-oriented guide for both enzymatic and non-enzymatic nucleic acid synthesis.