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The thesis explores the effectiveness of NHC-catalyzed annulation reactions involving nitroalkenes, enals, and beta-unsaturated carboxylic acids. It demonstrates that NHCs serve as efficient catalysts for the [4+2] annulation of beta-substituted nitroalkenes, extending the Rauhut-Currier reaction's applicability. Additionally, enals facilitate [4+2] annulations with azodicarboxylates through Gamma-addition, leading to valuable tetrahydropyridazinones and Gamma-amino acid derivatives. Furthermore, beta-unsaturated carboxylic acids are utilized to create acyl azolium intermediates for enantioselective [3+2] and [3+3] annulations.
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New Strategies for N-Heterocyclic Carbenes Catalyzed Annulations, Xiangyu Chen
- Language
- Released
- 2016
- product-detail.submit-box.info.binding
- (Hardcover)
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- Title
- New Strategies for N-Heterocyclic Carbenes Catalyzed Annulations
- Language
- English
- Authors
- Xiangyu Chen
- Publisher
- Springer Nature Singapore
- Released
- 2016
- Format
- Hardcover
- Pages
- 123
- ISBN13
- 9789811028984
- Category
- Chemistry
- Description
- The thesis explores the effectiveness of NHC-catalyzed annulation reactions involving nitroalkenes, enals, and beta-unsaturated carboxylic acids. It demonstrates that NHCs serve as efficient catalysts for the [4+2] annulation of beta-substituted nitroalkenes, extending the Rauhut-Currier reaction's applicability. Additionally, enals facilitate [4+2] annulations with azodicarboxylates through Gamma-addition, leading to valuable tetrahydropyridazinones and Gamma-amino acid derivatives. Furthermore, beta-unsaturated carboxylic acids are utilized to create acyl azolium intermediates for enantioselective [3+2] and [3+3] annulations.