New Strategies for N-Heterocyclic Carbenes Catalyzed Annulations

The thesis explores the effectiveness of NHC-catalyzed annulation reactions involving nitroalkenes, enals, and beta-unsaturated carboxylic acids. It demonstrates that NHCs serve as efficient catalysts for the [4+2] annulation of beta-substituted nitroalkenes, extending the Rauhut-Currier reaction's applicability. Additionally, enals facilitate [4+2] annulations with azodicarboxylates through Gamma-addition, leading to valuable tetrahydropyridazinones and Gamma-amino acid derivatives. Furthermore, beta-unsaturated carboxylic acids are utilized to create acyl azolium intermediates for enantioselective [3+2] and [3+3] annulations.