Uniqueness of 2-Oxo-Electrophiles Reactions with Typical Nucleophiles

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Aldehyde and its various electrophilic forms reactions and their pathways are changed steadily by an involvement of electron withdrawing 2-Oxo group. This 2-Oxo group in 2-Oxoaldehyde (2OA) makes distinctive than compare to the regular aldehyde as 2OA and its other variants enhance their electrophilicities to a peculiar level and that levels may adequate to overcome a new energy barrier for a newer reaction. In addition, this enhanced electrophilicity may cause to requirement of different reaction conditions, for example these reactions generally do not need the assistance of either acid or base catalyst that's quite common in aldehyde reactions. Consequently, these reactions may require different reaction parameters and thereby, produce newer reactions in terms of synthesis of either exigent chemical bonds (C-C, C-N, C-O, C-S and etc.) or biologically valuable functionalized heterocycles from cheaper materials in economical approaches. This 2-Oxo chemistry certainly offers a solution to the regular need to the synthetic chemistry.