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Focusing on confirmatory adaptive designs, this book offers a comprehensive review of their principles and techniques, emphasizing their evolution from group sequential designs. It details the process of conducting interim analyses to potentially halt trials while managing Type I error rates. Additionally, the text covers the flexibility of adaptive designs, allowing for data-driven modifications such as reassessing sample sizes, selecting treatment arms, or identifying specific sub-populations during the study.
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Group Sequential and Confirmatory Adaptive Designs in Clinical Trials, Gernot Wassmer, Werner Brannath
- Language
- Released
- 2016
- product-detail.submit-box.info.binding
- (Hardcover)
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- Title
- Group Sequential and Confirmatory Adaptive Designs in Clinical Trials
- Language
- English
- Authors
- Gernot Wassmer, Werner Brannath
- Publisher
- Springer International Publishing
- Released
- 2016
- Format
- Hardcover
- Pages
- 320
- ISBN13
- 9783319325606
- Category
- Health / Medicine, Mathematics
- Description
- Focusing on confirmatory adaptive designs, this book offers a comprehensive review of their principles and techniques, emphasizing their evolution from group sequential designs. It details the process of conducting interim analyses to potentially halt trials while managing Type I error rates. Additionally, the text covers the flexibility of adaptive designs, allowing for data-driven modifications such as reassessing sample sizes, selecting treatment arms, or identifying specific sub-populations during the study.