Female sex and ER-alpha modulate cardiac ischaemic remodeling
Cardiomyocyte-specific overexpression of estrogen receptor alpha provides cardioprotection in female mice
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More about the book
The study explores the protective role of estrogen receptors (ER) in myocardial injury, highlighting significant differences between sexes. Utilizing a transgenic mouse model with cardiomyocyte-specific ER overexpression, findings reveal that while both genders exhibit increased left ventricular mass, only females show improved cardiac outcomes post-myocardial infarction. These benefits include reduced ventricular fibrosis, enhanced angiogenesis, and increased JNK phosphorylation, suggesting that targeting ER in female cardiomyocytes could offer therapeutic advantages in treating ischemic heart disease.
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Female sex and ER-alpha modulate cardiac ischaemic remodeling, Xiang Zhang
- Language
- Released
- 2017
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- (Paperback)
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- Title
- Female sex and ER-alpha modulate cardiac ischaemic remodeling
- Subtitle
- Cardiomyocyte-specific overexpression of estrogen receptor alpha provides cardioprotection in female mice
- Language
- English
- Authors
- Xiang Zhang
- Released
- 2017
- Format
- Paperback
- Pages
- 92
- ISBN13
- 9783838151281
- Category
- Health / Medicine
- Description
- The study explores the protective role of estrogen receptors (ER) in myocardial injury, highlighting significant differences between sexes. Utilizing a transgenic mouse model with cardiomyocyte-specific ER overexpression, findings reveal that while both genders exhibit increased left ventricular mass, only females show improved cardiac outcomes post-myocardial infarction. These benefits include reduced ventricular fibrosis, enhanced angiogenesis, and increased JNK phosphorylation, suggesting that targeting ER in female cardiomyocytes could offer therapeutic advantages in treating ischemic heart disease.