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Female sex and ER-alpha modulate cardiac ischaemic remodeling
Cardiomyocyte-specific overexpression of estrogen receptor alpha provides cardioprotection in female mice
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92 pages
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The study explores the protective role of estrogen receptors (ER) in myocardial injury, highlighting significant differences between sexes. Utilizing a transgenic mouse model with cardiomyocyte-specific ER overexpression, findings reveal that while both genders exhibit increased left ventricular mass, only females show improved cardiac outcomes post-myocardial infarction. These benefits include reduced ventricular fibrosis, enhanced angiogenesis, and increased JNK phosphorylation, suggesting that targeting ER in female cardiomyocytes could offer therapeutic advantages in treating ischemic heart disease.
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- ISBN
- 9783838151281
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2017, paperback
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