Immune Responses to Viral Vectors Used in Gene Therapy

Exploring the intricate relationship between gene therapy and the immune system, this book delves into how immune responses impact the efficacy of viral vectors used in treatment. It covers various aspects, including the immune reactions to adenoviral and AAV vectors in both the central nervous system and systemic administration. Clinical experiences and experimental approaches are discussed, alongside the implications of immune control for HSV and lentiviral vectors. The text also addresses the genetics of immune responses and strategies for inducing tolerance in gene therapy.