Antihyperglycemic Activity of Oxazolidine Derivatives

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The research focuses on synthesizing a series of 3-benzyl-2-(4'-substituted phenyl)-4(5H)-(4''-nitrophenyl amino)-1,3-oxazolidines to enhance antihyperglycemic properties. These compounds were tested for their ability to lower blood glucose levels in both Streptozotocin and Sucrose-loaded rat models, demonstrating significant efficacy. The purity of the synthesized compounds was confirmed through various analytical methods, including IR, 1H-NMR, mass spectrometry, and elemental analysis, underscoring the thoroughness of the study.