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TOXIGENIC BACTERIAL PROTEASES AND THEIR INHIBITORS
Bacterial proteases production, purification and partial characterization
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The study focuses on the proteolytic bacterium Brevibacterium otitidis CBS-76, which produces a protease with a molecular weight of 47 KDa and significant glutamic acid content. Optimal enzyme activity occurs at 35ºC and pH 7.2, with inhibition by EDTA and activation by sodium arsenate. In vivo tests on mice reveal significant liver histological changes, including inactive heterochromatin and swollen mitochondria. Additionally, novel inhibitors derived from saccharin sodium demonstrate effective enzyme inhibition, highlighting potential biomedical applications.
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TOXIGENIC BACTERIAL PROTEASES AND THEIR INHIBITORS, Essam Kotb
- Language
- Released
- 2011
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- Title
- TOXIGENIC BACTERIAL PROTEASES AND THEIR INHIBITORS
- Subtitle
- Bacterial proteases production, purification and partial characterization
- Language
- English
- Authors
- Essam Kotb
- Publisher
- LAP LAMBERT Academic Publishing
- Publisher
- 2011
- Format
- Paperback
- Pages
- 176
- ISBN13
- 9783843391764
- Category
- Nature in general
- Description
- The study focuses on the proteolytic bacterium Brevibacterium otitidis CBS-76, which produces a protease with a molecular weight of 47 KDa and significant glutamic acid content. Optimal enzyme activity occurs at 35ºC and pH 7.2, with inhibition by EDTA and activation by sodium arsenate. In vivo tests on mice reveal significant liver histological changes, including inactive heterochromatin and swollen mitochondria. Additionally, novel inhibitors derived from saccharin sodium demonstrate effective enzyme inhibition, highlighting potential biomedical applications.