Regulation of Aldosterone Biosynthesis

The evolution of research in endocrinology over sixteen years is highlighted, showcasing significant advancements in understanding aldosterone biosynthesis. Key developments, such as the introduction of sensitive radioimmunoassays and the isolation of zona glomerulosa cells, revolutionized the field. The text reflects on the absence of various hormonal discoveries and clinical syndromes at that time, emphasizing the progression of knowledge regarding the physiological and pathological regulation of aldosterone, including the roles of newly identified substances.