Anti-Cancer N-Heterocyclic Carbene Complexes of Gold(III), Gold(I) and Platinum(II)

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The thesis explores innovative gold- and platinum-based anti-cancer agents that operate through unique mechanisms distinct from cisplatin. It emphasizes the use of N-heterocyclic carbene (NHC) ligands, enhancing the stability and reactivity of metal complexes. Key findings include Au(III) complexes that serve as both fluorescent probes and anti-cancer agents, a dinuclear gold(I) complex that effectively inhibits tumor growth in mice without side effects, and luminescent platinum(II) complexes that target the endoplasmic reticulum, inducing cell apoptosis. The research underscores the clinical promise of these metal complexes in cancer therapy.