Beyond Single Genes: The Role of Multiple Variants in Complex Disease

The exploration of complex diseases reveals that multiple gene variations, rather than a single faulty gene, significantly impact conditions like heart disease and diabetes. Researchers conceptualize these diseases as a tangled web of genetic variants, where each variant contributes subtly to disease risk. This polygenic inheritance explains familial patterns in disease occurrence while highlighting the role of environmental factors like diet and lifestyle. Understanding this intricate interplay is essential for developing accurate risk prediction tools and personalized treatments tailored to individual genetic profiles.