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Gold(I,III) Complexes Designed for Selective Targeting and Inhibition of Zinc Finger Proteins
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Focusing on the therapeutic potential of Au (I, III) complexes, the book investigates their selective inhibition of zinc finger proteins (ZnFs), particularly targeting the HIV-1 nucleocapsid protein and the human transcription factor Sp1. Innovative techniques such as Travelling-Wave Ion Mobility coupled with Mass Spectrometry and X-ray Absorption Spectroscopy are employed to elucidate the coordination sphere of gold adducts. Additionally, the organometallic compound [Au (bnpy)Cl2] is assessed for its ability to inhibit ZnFs through C-S coupling, revealing promising insights for future treatments.
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Gold(I,III) Complexes Designed for Selective Targeting and Inhibition of Zinc Finger Proteins, Raphael Enoque Ferraz de Paiva
- Language
- Released
- 2019
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- Title
- Gold(I,III) Complexes Designed for Selective Targeting and Inhibition of Zinc Finger Proteins
- Language
- English
- Publisher
- Springer International Publishing
- Publisher
- 2019
- Format
- Paperback
- Pages
- 192
- ISBN13
- 9783030131500
- Category
- Chemistry, Nature in general
- Description
- Focusing on the therapeutic potential of Au (I, III) complexes, the book investigates their selective inhibition of zinc finger proteins (ZnFs), particularly targeting the HIV-1 nucleocapsid protein and the human transcription factor Sp1. Innovative techniques such as Travelling-Wave Ion Mobility coupled with Mass Spectrometry and X-ray Absorption Spectroscopy are employed to elucidate the coordination sphere of gold adducts. Additionally, the organometallic compound [Au (bnpy)Cl2] is assessed for its ability to inhibit ZnFs through C-S coupling, revealing promising insights for future treatments.