IARC Scientific Publications - 83: Long-term and Short-term Assays for Carcinogens

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This volume contains the papers presented at a meeting held in December 1985 to review the conduct and use of long- and short- term assays for the detection of chemical carcinogens. The meeting was attended by about 60 experts in the fields of carcinogenesis, mutagenesis, and cell biology.The series of reports on long-term carcinogenicity assays pay particular attention to three the role of pharmacokinetic data, early preneoplastic lesions in carcinogenesis, and the possibility for discerning the relative contribution of carcinogens to various stages of carcinogenesis. Thereports on short-term assays summarize, among other points, the principle and scientific basis of each assay and its relevance to carcinogen detection and to the multistage process of carcinogenesis.