Domenico Ribatti Books

Exploring the intricate relationship between tumors and their surrounding microenvironment, this book delves into how various factors influence tumor growth and progression. It examines cellular interactions, signaling pathways, and the role of immune cells, providing a comprehensive understanding of the tumor microenvironment's impact on cancer biology. By integrating cutting-edge research and insights, it aims to highlight potential therapeutic strategies targeting these interactions to inhibit tumor expansion, making it essential for researchers and clinicians in oncology.

Focusing on the historical development of immune surveillance against tumors, this book examines the evolution of immunotherapy and the concept of immunoediting. It presents evidence supporting and challenging the immune surveillance theory, highlighting the immune system's critical role in detecting tumors. The text discusses tumor cell strategies to evade immune attacks, supported by findings from animal models and clinical cases. It also addresses the paradox of cancer development in individuals with normal immune function, illustrating the complexity of tumor immunity.

Mast cells are ancient immune cells found throughout the human body, particularly near connective tissues and surfaces exposed to the environment. They play a crucial role in initiating defense mechanisms against foreign invaders and are central to type I hypersensitivity reactions. Beyond allergic responses, mast cells are involved in host defense against various pathogens and contribute to both acquired and innate immunity. Additionally, they have significant non-immunological functions, influencing tissue homeostasis, remodeling, fibrosis, and angiogenesis.

Exploring the intricacies of vascular system development, this book delves into the latest research and discoveries in the field. It highlights the molecular mechanisms and genetic factors that influence vascular formation, providing a comprehensive overview of both normal and pathological processes. The text serves as a valuable resource for researchers and clinicians, offering insights that could lead to innovative therapeutic approaches for vascular-related diseases.