The story introduces the Year Monster, a character from ancient Chinese folklore, who disrupts the Chinese New Year festivities. Through a vibrant rhyming poem, children learn about the significance of dumplings, firecrackers, and red lanterns while discovering how to outsmart the mischievous monster using wit and clever tricks. The engaging illustrations enhance the festive spirit, making it a delightful exploration of cultural traditions and the importance of resilience during celebrations.
The Involvement of BNIP3 and Calcium in Cyanide-induced Neurotoxicity
The study investigates the cell death mechanisms triggered by cyanide exposure, focusing on the role of BNIP3 in dopaminergic cell lines. Cyanide activates the HIF-1 pathway, leading to increased BNIP3 expression, which initiates mitochondria-mediated apoptosis. In mice, sublethal cyanide doses elevate BNIP3 in the midbrain, correlating with dopaminergic neuron loss. BNIP3's localization in the endoplasmic reticulum and mitochondria enhances calcium release and uptake, while Bax co-localization with BNIP3 is crucial for mediating cell death through calcium signaling.