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Biotechnology Advances in Biochemical Engineering Biotechnology

Exploring the innovative applications of solvent extraction in biotechnology, this book delves into various techniques and methodologies used for the separation and purification of biomolecules. It covers a range of topics including the principles of solvent extraction, its role in bioprocessing, and case studies that highlight its effectiveness in different biotechnological contexts. Aimed at researchers and professionals, it provides insights into optimizing processes and improving yield in biotechnological applications.

This special volume is dedicated to Professor Wolf-Dieter Deckwer on his 60th birthday. It features a collection of 11 outstanding review articles primarily authored by his former students, associates, colleagues, and friends. The title reflects Deckwer's research interests and scientific pursuits over more than 20 years in biochemical engineering, particularly during his leadership of the Biochemical Engineering Division at GBF (German National Research Center for Biotechnology). He has significantly advanced the development of both "software tools," including analytical methods and mathematical models for monitoring cellular processes, and "hardware tools," such as computer control systems and bioreactors for producing a variety of bioproducts at semi-production scale. The volume reviews new developments in these crucial tools in biochemical engineering. Deckwer was a pioneer in emphasizing the need for an integrated approach to bioprocess development. By establishing "Integrated Bioprocess Development" as a key research focus at GBF in 1990, he actively promoted this concept, contributing to the field's evolution.

Alongside presenting the fundamentals, this book reviews the state of the art of mathematical modeling and control of bioprocesses, while demonstrating the application in various biological systems important to industry. At the same time, the application of different types of models and control strategies are illustrated, taking into account the recent developments in reactor modeling. In addition to modeling and control, the metabolic flux analysis and the metabolic design and their application to bioprocesses are considered.

The state of the art of the bioengineering aspects of the morphology of microorganisms and their relationship to process performance are described in this volume. Materials and methods of the digital image analysis and mathematical modeling of hyphal elongation, branching and pellet formation as well as their application to various fungi and actinomycetes during the production of antibiotics and enzymes are presented.