Manfred T. Reetz Book order

Written by one of the pioneers, this book presents enzyme engineering and its applications at its best. Beside established topics like enzyme activity and selectivity, emerging fields like machine learning and AI are presented, too.

Authored by one of the world's leading organic chemists, this authoritative reference provides an overview of basic strategies in directed evolution and introduces common gene mutagenesis, screening and selection methods. Throughout the text, emphasis is placed on methodology development to maximize efficiency, reliability and speed of the experiments and to provide guidelines for efficient protein engineering. Professor Reetz highlights the application of directed evolution experiments to address limitations in the field of enzyme selectivity, substrate scope, activity and robustness. He critically reviews recent developments and case studies, takes a look at future applications in the field of organic synthesis, and concludes with lessons learned from previous experiments.

Focusing on advancements in titanium chemistry, this book explores its applications in organic synthesis, particularly through the titanation of classical carbanions. This process enhances selectivity in reactions involving organic compounds like aldehydes and ketones. The variability of the ligand X at titanium allows for precise control over the reagents' electronic and steric properties, aiding in predicting stereochemical outcomes. While achieving a complete understanding of structure-reactivity correlations remains a challenge, significant progress in organotitanium chemistry is discussed, supported by extensive physical and computational data.

This book provides an excellent overview on state-of-the-art of modern organocatalysis. It presents the contributions from leading experts, with backgrounds in academia and industry, to an Ernst Schering Research Foundation Symposium held in April 2007. It will be of interest to those who want a general overview of the topic, but also to those who want to learn more about the state-of-the-art, current trends and perspectives in this highly dynamic field of research.