Drug Delivery To the Lung

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This book explores aerosol treatment for lung diseases, highlighting advancements in dosage understanding and innovations in device technology for clinical use. It examines the behavior of inspired spherical particles in the respiratory tract and includes over 1300 references, illustrations, tables, photographs, and micrographs. The text outlines the history of inhaled medications for respiratory conditions, discusses respiratory structure relevant to inhalation therapy, and emphasizes developmental changes. It compares existing in vitro/in vivo correlations for key aerosol modalities with lung model predictions, reviews particle diameter measurement and aerosol testing methods, and analyzes the clinical effects of altering drug deposition sites. The book also surveys the development of novel nebulizer systems, breath-actuated and spacer devices for children, and evaluates dry-powder and pressurized metered-dose inhalers. Additionally, it considers the transition from CFCs to environmentally friendly propellants. This comprehensive resource provides clinicians with essential insights into drug delivery via nebulization, making it an invaluable reference for pulmonologists, physiologists, pharmaceutical scientists, and students in related fields.