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Colm Duffy's thesis explores stable lipoxin analogues' chemistry and biology. He synthesized a pyridine-containing LXA4 analogue in enantiomerically pure form and found that both epimers suppress key cytokines in inflammatory diseases, with the (R)-epimer being the most effective. He also developed a thiophene-containing analogue with notable biological activity, inspiring further research.
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Heteroaromatic Lipoxin A4 Analogues, Colm Duffy
- Language
- Released
- 2014
- product-detail.submit-box.info.binding
- (Paperback)
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- Subtitle
- Synthesis and Biological Evaluation
- Language
- English
- Authors
- Colm Duffy
- Publisher
- Springer, Berlin
- Released
- 2014
- Format
- Paperback
- Pages
- 152
- ISBN13
- 9783642438929
- Series
- Springer Theses
- Tags
- Non-Fiction
- Description
- Colm Duffy's thesis explores stable lipoxin analogues' chemistry and biology. He synthesized a pyridine-containing LXA4 analogue in enantiomerically pure form and found that both epimers suppress key cytokines in inflammatory diseases, with the (R)-epimer being the most effective. He also developed a thiophene-containing analogue with notable biological activity, inspiring further research.