Probability Models for DNA Sequence Evolution

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Exploring the underlying forces behind DNA sequence variability, the authors delve into probability models such as the Wright-Fisher model and the coalescent. They address complexities introduced by factors like nonconstant population size, recombination, and population subdivision, alongside different forms of natural selection. This theoretical framework paves the way for examining statistical tests aimed at identifying deviations from neutral evolution, providing a comprehensive analysis of genetic variability and evolutionary dynamics.