Multicomponent synthesis of 4H-pyran-3-carboxylate derivatives

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The book details a novel one-pot multi-component reaction (MCR) utilizing ethyl 6-amino-5-cyano-2-methyl-4H-pyran-3-carboxylate derivatives, catalyzed by urea in a water-ethanol system. It highlights the efficiency of the reaction involving aldehydes, malononitrile, and ethylacetoacetate at room temperature, yielding products with minimal effort. The synthesized compounds are thoroughly validated using Mass, 1H-NMR, IR, and melting point analysis. The method is noted for its mild conditions, high yields, and the reusability of the reaction media, emphasizing its eco-friendly approach.